Notably, some skin care companies are not waiting for such studies (or perhaps have their own in-house research data) and are already including panthenol in anti-wrinkle formulations. Most studies of topical effects of panthenol have been short-term, typically 3-4 weeks or so. sodium PCA), D-panthenol also works by strengthening, revitalizing and leak-proofing the skin's protective outer layers (epidermis and stratum corneum) thus reducing water loss. Find patient medical information for Zinc Oxide-Vitamin B5-Vit E Topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Here's everything you need to know about adding vitamin-enriched skincare products to your routine. Here, BAZAAR's deep-dive into why niacinamide should be your new skincare hero. Vitamin A. It prevents skin irritation, stimulates skin regeneration and promotes wound healing. Panthenol is known to stimulate the proliferation of dermal fibroblasts. Caution: The effects of long-term use of topical panthenol are unknown. The topical use of dexpanthenol, the stable alcoholic analog of pantothenic acid, is based on good skin penetration and high local concentrations of dexpanthenol when administered in an adequate vehicle, such as water-in-oil emulsions. Adding topical niacinamide to your skin-care routine is simple and low risk: Buy a product that contains it, and apply as directed. It restores hydration to dry skin as well as somewhat protects normal skin from drying effects of harsh detergents. Notably, some skin care companies are not waiting for such studies (or perhaps have their own in-house research data) and are already including panthenol in anti-wrinkle formulations. Purely moisturizing effects of panthenol appear to be more immediate both D and L panthenol chemically attract water. More research is needed to determine which skin effects of panthenol occurs via boosting the skin levels of vitamin B5 and which through other mechanisms. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse Sensitive skin: A 2002 "American Journal of Clinical Dermatology" paper notes that the topical use of provitamin B5 carries a low risk of adverse reaction such as irritation or sensitivity. Also, giving B5 orally may help decrease facial acne as shown in a study of 48 patients (6). If you cannot find a D-panthenol product with suitable concentration, texture and/or composition, you can use a DIY approach. While purchasing the best topical skincare products can certainly help, vitamins, minerals, and supplements also play an essential role in a well-rounded skincare regimen. D-panthenol also improves superficial skin damage (seen in dry, rough, chafed skin) by helping regenerate/strengthen the epidermis and stratum corneum (outer skin layers) and thus improving the skin's protective barrier. Ive had very very very oily skin after my acne treatment full of antibiotics creams, ive had enormous big pores, im taking 2g-4g of vitamin b5 daily and my skin hasnt been soo great looking for years !!